Structure, Regulation, and Denaturation of Rabbit Muscle Glycogen Phosphorylase b

N. B. Livanova,^1,2 and B. A. Kornilaev¹

¹Bakh Institute of Biochemistry, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 117071 Russia; fax: (7-095) 954-27-32; E-Mail: inbio@glas.apc.org ²To whom correspondence should be addressed.

Submitted June 17, 1996.

This review summarizes data on structure, allosteric regulation, and denaturation of muscle glycogen phosphorylase b. Specific attention is paid to correlations between the structure and function of phosphorylase b and the molecular mechanisms of its allosteric regulation. Data on the chemical and thermal denaturation of phosphorylase b is reviwed.

KEY WORDS: glycogen phosphorylase, allosteric regulation, protein structure, denaturation, thermal stability.

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