* To whom correspondence should be addressed.
Received May 28, 1997
The role of platelet-activating factor (PAF, a phospholipid compound) in regulation of cell functions and cell--cell interactions is reviewed. The biological effects of PAF on platelets, neutrophils, basophils, eosinophiles, lymphocytes, and endothelial cells are described. Mechanisms of cell activation by PAF are discussed. Interactions of PAF with other biological regulators (prostaglandins, leukotrienes, NO, tumor necrosis factor, and interleukins) are considered.
KEY WORDS: platelet-activating factor, cells