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REVIEW: The Bioregulatory Role of Platelet-Activating Factor in Intracellular Processes and Cell--Cell Interactions

V. I. Kulikov* and G. I. Muzya

Research and Development Center for Medical Biotechnology, Ministry of Health of the Russian Federation, ul. Shchukinskaya 6, Moscow, 123182 Russia; fax: (095) 190-0100

* To whom correspondence should be addressed.

Received May 28, 1997
The role of platelet-activating factor (PAF, a phospholipid compound) in regulation of cell functions and cell--cell interactions is reviewed. The biological effects of PAF on platelets, neutrophils, basophils, eosinophiles, lymphocytes, and endothelial cells are described. Mechanisms of cell activation by PAF are discussed. Interactions of PAF with other biological regulators (prostaglandins, leukotrienes, NO, tumor necrosis factor, and interleukins) are considered.
KEY WORDS: platelet-activating factor, cells