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REVIEW: Correlation between Bioeffector Characteristics of Sphingolipids and the Structure of Their Hydrophobic Fragment

E. V. Dyatlovitskaya

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow GSP-7, 117871 Russia; fax: (095) 335-7103; E-mail: jgmol@ibch.siobc.ras.ru

Submitted June 9, 1997
The effect of the structure of the hydrocarbon sphingoid base chain (length, presence of double bonds, and steric configuration of functional groups) and the length of the fatty acid residue of a ceramide molecule on the bioregulatory activities of sphingoids and ceramides is reviewed. Particular emphasis is placed on the role of functional groups (OH- and NH2-) typical of the sphingoid chain.
KEY WORDS: bioeffector, sphingenine, stereospecificity, chemical structure, ceramide, sphingolipid