REVIEW: Plasminogen Activators in Vascular Remodeling and Angiogenesis

Ye. V. Parfyonova^*, O. S. Plekhanova, and V. A. Tkachuk

Russian Cardiology Research Center, Ministry of Health of the Russian Federation, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552 Russia; fax: (095) 414-6712; E-mail: Yeparfyon@cardio.ru

^* To whom correspondence should be addressed.

Received August 1, 2001; Revision received October 15, 2001

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This review considers cellular and molecular mechanisms of the involvement of plasminogen activators in extracellular proteolysis and cell migration and proliferation. The role of plasminogen activators in vascular remodeling in atherosclerosis, restenosis, and angiogenesis is discussed.

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KEY WORDS: urokinase, tissue plasminogen activator, cell migration, vascular remodeling, restenosis, angiogenesis

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