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REVIEW: Biochemical Problems of Regulation by Oligopeptides

A. A. Zamyatnin

Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr. 33, Moscow 119071, Russia; fax: (7-095) 954-2732; E-mail: aaz@inbi.ras.ru
Current address: Universidad Tecnica Federico Santa Maria, Avenida Espana 1680, Valparaiso, Chile; E-mail: aaz@inf.utfsm.cl

Received July 9, 2004
Some problems are considered which arise in biochemical studies on structure and function of natural oligopeptides consisting of 2-50 amino acid residues. The problems under consideration include the generation of oligopeptides from precursors, chemical structure, the role of functionally important radicals and spatial configuration, and structure-function relationships. Different types of regulation are shown mainly for oligopeptides involved in muscle contraction.
KEY WORDS: oligopeptide, precursor, content, receptor, chemical structure, homology, conformation, function, activity, regulation, interaction, enzyme, muscle contraction, EROP-Moscow knowledge database, alignment