Studies on DNA Binding to Metal Complexes of Sal₂trien

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Zhou Cheng-Yong^1,2, Xi Xiao-Li¹, and Yang Pin^1*

¹Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan, Shanxi 030006, PR China; fax: +86 (351) 701-1022; E-mail: yangpin@sxu.edu.cn

²Department of Biochemistry, Changzhi College, Shanxi Changzhi 046011, PR China

^* To whom correspondence should be addressed.

Received June 2, 2006; Revision received September 18, 2006

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The complexes [Fe(Sal₂trien)]NO₃ and Cu(Sal₂trien) have been synthesized and their interaction with calf thymus DNA has been investigated for the first time using UV spectra, fluorescence spectra, thermal denaturation, and viscosity measurements. The experimental results show conformably that the mode of binding of the complex [Fe(Sal₂trien)]NO₃ to DNA is nonclassical electrostatic action, but the mode of binding of the complex Cu(Sal₂trien) to DNA is classical intercalation.

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KEY WORDS: DNA binding, [Fe(Sal₂trien)]NO₃, Cu(Sal₂trien), calf thymus DNA

DOI: 10.1134/S000629790701004X

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