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REVIEW: Role of Toll-Like Receptors in Tissue Repair and Tumorigenesis

S. Rakoff-Nahoum and R. Medzhitov*

Howard Hughes Memorial Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510 USA; E-mail: ruslan.medzhitov@yale.edu

* To whom correspondence should be addressed.

Received December 11, 2007
Toll-like receptors (TLRs) play a critical role in host defense from microbial infection. TLRs recognize conserved molecular structures produced by microorganisms and induce activation of innate and adaptive immune responses. The inflammatory responses induced by TLRs play an important role TLRs not only in host defense from infection, but also in tissue repair and regeneration. This latter function of TLRs can also contribute to tumorigenesis. Here we review recent progress in understanding the role of TLRs in cancer development.
KEY WORDS: Toll-like receptors, tissue repair, tumorigenesis

DOI: 10.1134/S0006297908050088