REVIEW: Chemotaxis: Movement, Direction, Control

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A. V. Vorotnikov

Department of Biochemistry and Molecular Medicine, Faculty of Basic Medicine, Lomonosov Moscow State University, 119192 Moscow, Russia; E-mail: vorotnikov@fbm.msu.ru

Received June 23, 2011; Revision received July 21, 2011

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This review focuses on basic principles of motility in different cell types, formation of the specific cell structures that enable directed migration, and how external signals are transduced into cells and coupled to the motile machinery. Feedback mechanisms and their potential role in maintenance of internal chemotactic gradients and persistence of directed migration are highlighted.

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KEY WORDS: cell motility, directed migration, chemotaxis, signal transduction, feedback regulation

DOI: 10.1134/S0006297911130104

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