Role of Oxidative Stress and Mitochondria in Onset of Urinary Bladder Dysfunction under Acute Urine Retention

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V. I. Kirpatovsky^1,2*, E. Y. Plotnikov^2,3, I. S. Mudraya¹, S. A. Golovanov¹, V. V. Drozhzheva¹, R. A. Khromov¹, D. Y. Chernikov¹, V. P. Skulachev^2,3, and D. B. Zorov^2,3

¹Research Institute of Urology, Russian Ministry of Health, 3-ya Parkovaya ul. 51, 105425 Moscow, Russia; fax: (499) 165-0911; E-mail: vladkirp@yandex.ru

²Scientific Research Institute of Mitoengineering, Lomonosov Moscow State University, 119992 Moscow, Russia; fax: (495) 939-5945

³Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; fax: (495) 939-0338

^* To whom correspondence should be addressed.

Received December 21, 2012; Revision received February 4, 2013

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Acute urine retention is a frequent complication in patients with benign hyperplasia of the prostate gland. According to studies made on experimental animals and people, it is accompanied by the deterioration of the bladder blood supply. This study attempts to explore the relationship of intramural blood flow, production of reactive oxygen species, and functional state of the bladder detrusor in modeling of acute urine retention in rats, as well as the impact of mitochondria-targeted antioxidants (which are supposed to alleviate the effects of oxidative stress induced by experimental ischemia) on these parameters. The study showed beneficial effects of mitochondria-targeted antioxidant SkQR1 in preventing damage of the bladder caused by acute urinary retention, which suggests the therapeutic use of this type of compounds for the treatment of ischemic abnormalities of the urinary bladder.

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KEY WORDS: ischemia, oxidative stress, urine retention, urinary bladder, mitochondria-targeted antioxidants, SkQ, mitochondria

DOI: 10.1134/S0006297913050131

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