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REVIEW: Dynorphins in Regulation of Immune System Functions

S. V. Gein1,2

1Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, ul. Goleva 13, 614081 Perm, Russia; E-mail: gein@iegm.ru

2Perm State University, ul. Bukireva 15, 614990 Perm, Russia

Received October 28, 2013; Revision received January 9, 2014
Dynorphins constitute a family of opioid peptides manifesting the highest affinity for κ-opiate receptors. Immune system cells are known to express a κ-receptor similar to that in the central nervous system, and as a consequence dynorphins are involved in the interaction between cells of the nervous and immune systems. In this review, data on dynorphin structure are analyzed and generalized, the κ-opiate receptor is characterized, and data on the regulation by dynorphins of functioning of the innate and adaptive immunity cells are summarized.
KEY WORDS: dynorphin, κ-opiate receptor, immunoregulatory effects, monocytes/macrophages, lymphocytes, NK-cells, dendritic cells, cAMP

DOI: 10.1134/S0006297914050034