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Influence of 10-(6′-Plastoquinonyl)decyltriphenylphosphonium (SkQ1) on Oxidative Status in Rats with Protamine Sulfate-Induced Hyperglycemia

Ya. G. Voronkova1, T. N. Popova1*, A. A. Agarkov1, and M. V. Skulachev2

1Voronezh State University, Department of Medical Biochemistry and Microbiology, 394006 Voronezh, Russia; E-mail: tpopova@bio.vsu.ru

2Lomonosov Moscow State University, Institute of Mitoengineering, 119991 Moscow, Russia; E-mail: info@skq-project.ru

* To whom correspondence should be addressed.

Received April 7, 2015; Revision received July 23, 2015
An influence of 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) on oxidative status and activity of some antioxidant enzymes in the liver and blood serum from rats was examined during experimental hyperglycemia developed after injecting protamine sulfate. It was found that SkQ1 lowered glycemic level in rats treated with protamine sulfate. Moreover, it was also accompanied by restoration of the normal range of biochemiluminescence parameters indicating the rate of ongoing free radical processes, magnitude of primary products of lipid peroxidation such as diene conjugates, activity of aconitate hydratase, and level of citrate in rat liver and blood. Hence, it was demonstrated that activity of superoxide dismutase and catalase, increasing during hyperglycemia, was decreased after administering SkQ1. This might be related to the ability of SkQ1 to normalize free-radical homeostasis imbalanced during hyperglycemia.
KEY WORDS: hyperglycemia, SkQ1, free radical oxidation, biochemiluminescence, superoxide dismutase, catalase, aconitate hydratase, citrate

DOI: 10.1134/S0006297915120093