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Effect of Long-Term Treatment with Antioxidant SkQ1 Added to Drinking Water on Cytochromes P450 Level in Rat Liver

K. N. Myasoedova1,2* and D. N. Silachev2,3

1Lomonosov Moscow State University, Faculty of Fundamental Medicine, 119991 Moscow, Russia; E-mail: skulach@genebee.msu.ru; skulach@belozersky.msu.ru

2Lomonosov Moscow State University, Institute of Mitoengineering, 119991 Moscow, Russia; fax: +7 (495) 939-5945

3Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, 119991 Moscow, Russia; fax: +7 (495) 939-0338

* To whom correspondence should be addressed.

Received October 1, 2015
Mitochondria-targeted cationic antioxidant plastoquinonyl decyltriphenylphosphonium (SkQ1) added to drinking water in therapeutic doses (250 nmol/kg per day) for a long time (up to 24 months) does not induce cytochromes P450 in rat liver.
KEY WORDS: cytochrome P450, SkQ1, mitochondria-targeted antioxidant

DOI: 10.1134/S0006297915120123