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REVIEW: Molecular and Cellular Interactions between Mother and Fetus. Pregnancy as a Rejuvenating Factor

V. A. Popkov1,2, D. N. Silachev1, S. S. Jankauskas1, L. D. Zorova3, I. B. Pevzner1, V. A. Babenko2,4, E. Y. Plotnikov1*, and D. B. Zorov1*

1Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, 119991 Moscow, Russia; E-mail: plotnikov@genebee.msu.ru, zorov@genebee.msu.su

2Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, 119991 Moscow, Russia

3Lomonosov Moscow State University, International Laser Center, 119991 Moscow, Russia

4Research Center of Obstetrics, Gynecology and Perinatology, 117997 Moscow, Russia

* To whom correspondence should be addressed.

Received August 26, 2016; Revision received September 16, 2016
Aging is associated with a decline of various body functions, including ability to regenerate. Over recent decades, it has been demonstrated that some of these changes could be reversed in response to factors originating from a young organism, for example, fetal stem cells or “young blood” in models of heterochronic parabiosis. Pregnancy might be considered as parabiotic model of the interaction between two organisms of different age. In this work, we analyzed and summarized data on the effects of pregnancy on the maternal organism that confirm the hypothesis that pregnancy rejuvenates the mother’s organism or slows its aging.
KEY WORDS: pregnancy, rejuvenation, aging

DOI: 10.1134/S0006297916120099