MINI-REVIEW: Mitochondrial Translation Initiation Factor 3: Structure, Functions, Interactions, and Implication in Human Health and Disease

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I. V. Chicherin^1,2,a*, M. V. Baleva¹, S. A. Levitskii¹, E. B. Dashinimaev^3,4,b, and I. A. Krasheninnikov¹

¹Lomonosov Moscow State University, Faculty of Biology, 119234 Moscow, Russia

²Institute of Functional Genomics, Lomonosov Moscow State University, 119234 Moscow, Russia

³Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia

⁴Pirogov Russian National Research Medical University, 117977 Moscow, Russia

^* To whom correspondence should be addressed.

Received March 29, 2019; Revised April 25, 2019; Accepted June 23, 2019

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Mitochondria are essential organelles of eukaryotic cell that provide its respiratory function by means of the electron transfer chain. Expression of mitochondrial genes is organized in a bacterial-like manner; however multiple evolutionary differences are observed between the two systems, including translation initiation machinery. This review is dedicated to the mitochondrial translation initiation factor 3 (IF3mt), which plays a key role in the protein synthesis in mitochondria. Involvement of IF3mt in human health and disease is discussed.

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KEY WORDS: IF3mt, mitochondria, translation, ribosome, Parkinson’s disease

DOI: 10.1134/S0006297919100031

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