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REVIEW: Role of MicroRNAs in the Regulation of Redox-Dependent Processes

E. V. Kalinina1,a*, V. I. Ivanova-Radkevich1, and N. N. Chernov1

1Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia

* To whom correspondence should be addressed.

Received May 31, 2019; Revised July 4, 2019; Accepted July 4, 2019
Cellular redox homeostasis involves a combination of redox processes and corresponding regulatory systems and represents an important factor ensuring cell viability. Redox-dependent regulation of cellular processes is a multi-level system including not only proteins and enzyme complexes, but also non-coding RNAs, among which an important role belongs to microRNAs. The review focuses on the involvement of miRNAs in the redox-dependent regulation of both ROS (reactive oxygen species)-generating enzymes and antioxidant enzymes with special emphasis on the effects of miRNAs on redox-dependent processes in tumor cells. The impact of ROS on the miRNA expression and the role of the ROS/miRNA feedback regulation in the cell redox state are discussed.
KEY WORDS: reactive oxygen species, cellular redox homeostasis, microRNA

DOI: 10.1134/S0006297919110026