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REVIEW: Segregation of α- and β-Globin Gene Cluster in Vertebrate Evolution: Chance or Necessity?

Olga V. Iarovaia1,a*, Sergey V. Ulianov1,2, Elena S. Ioudinkova1, and Sergey V. Razin1,2

1Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia

2Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia

* To whom correspondence should be addressed.

Received July 22, 2022; Revised August 18, 2022; Accepted August 19, 2022
The review is devoted to the patterns of evolution of α- and β-globin gene domains. A hypothesis is presented according to which segregation of the ancestral cluster of α/β-globin genes in Amniota occurred due to the performance by α-globins and β-globins of non-canonical functions not related to oxygen transport.
KEY WORDS: evolution of α- and β-globin genes, regulation of transcription, non-canonical functions of α- and β-globins

DOI: 10.1134/S0006297922090140