REVIEW: YB-1 Protein in Breast Cancer (Scientific and Personal Meetings with Professor Ovchinnikov)

---

Gelena P. Guens^a

Department of Oncology and Radiation Therapy, Yevdokimov Moscow State University of Medicine and Dentistry, 127473 Moscow, Russia

Received September 14, 2021; Revised October 4, 2021; Accepted October 5, 2021

---

In the article, the author examines the properties of Y-box-binding protein (YB-1) and expression of the YBX-1 gene in various malignant tumors and provides the data from her own prospective study in breast cancer patients. YB-1 is a member of the highly conserved family of cold shock proteins with multiple functions in the cytoplasm and cell nucleus. YB-1 is involved in embryogenesis; it ensures cell proliferation and protects cell from the action of various aggressive environmental factors. In adult organisms, YB-1 is involved in a variety of cellular functions that regulate malignant phenotype in several types of tumors. YB-1 is a molecular marker of tumor progression that can be used in clinical practice as both prognostic factor and a target for anticancer therapy. Our prospective clinical study showed that expression of YB-1 mRNA is an independent prognostic factor, as breast cancer patients expressing YB-1 have a lower disease-free survival rate, regardless of the tumor stage and biological subtype. We recommend determining the level of YB-1 mRNA expression as a prognostic test in breast cancer patients.

---

KEY WORDS: YB-1, breast cancer, predictive test, the hallmarks of cancer

DOI: 10.1134/S0006297922140073

---