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REVIEW: YB-1 Protein in Breast Cancer (Scientific and Personal Meetings with Professor Ovchinnikov)

Gelena P. Guensa

Department of Oncology and Radiation Therapy, Yevdokimov Moscow State University of Medicine and Dentistry, 127473 Moscow, Russia

Received September 14, 2021; Revised October 4, 2021; Accepted October 5, 2021
In the article, the author examines the properties of Y-box-binding protein (YB-1) and expression of the YBX-1 gene in various malignant tumors and provides the data from her own prospective study in breast cancer patients. YB-1 is a member of the highly conserved family of cold shock proteins with multiple functions in the cytoplasm and cell nucleus. YB-1 is involved in embryogenesis; it ensures cell proliferation and protects cell from the action of various aggressive environmental factors. In adult organisms, YB-1 is involved in a variety of cellular functions that regulate malignant phenotype in several types of tumors. YB-1 is a molecular marker of tumor progression that can be used in clinical practice as both prognostic factor and a target for anticancer therapy. Our prospective clinical study showed that expression of YB-1 mRNA is an independent prognostic factor, as breast cancer patients expressing YB-1 have a lower disease-free survival rate, regardless of the tumor stage and biological subtype. We recommend determining the level of YB-1 mRNA expression as a prognostic test in breast cancer patients.
KEY WORDS: YB-1, breast cancer, predictive test, the hallmarks of cancer

DOI: 10.1134/S0006297922140073