REVIEW: Role of YB-1 Protein in Inflammation

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Ekaterina Yu. Rybalkina¹ and Natalia I. Moiseeva^1,a*

¹Blokhin National Research Center of Oncology, Ministry of Health of the Russian Federation, 115478 Moscow, Russia

^* To whom correspondence should be addressed.

Received October 8, 2021; Revised October 25, 2021; Accepted October 27, 2021

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This review discusses the role of the multifunctional DNA/RNA-binding protein YB-1 in inflammation. YB-1 performs multiple functions in the cell depending on its location: it acts as transcriptional factor for many genes in the nucleus, regulates translation and stability of mRNA in the cytoplasm, and becomes a paracrine factor when secreted from the cells. The review presents the data on the YB-1-mediated regulation of inflammation-associated genes, as well as results of studies on the YB-1 role in animal model of various inflammatory diseases, such as glomerulonephritis, tubulointerstitial fibrosis, and bacterial sepsis, and on the YB-1 expression in different human diseases associated with inflammatory processes in kidney, liver, and endometrium. The last section of the review presents several approaches to the regulation of YB-1 with small molecules in the treatment of inflammatory diseases.

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KEY WORDS: YB-1, inflammation, fibrosis, glomerulonephritis, Notch3, cytokines, chemokines

DOI: 10.1134/S0006297922140085

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