REVIEW: Pathogenetic Mechanisms of Mental Disorders: Endogenous Intoxication

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Marat G. Uzbekov^a

Moscow Research Institute of Psychiatry, Serbsky National Research Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, 107258 Moscow, Russia

Received December 27, 2022; Revised February 7, 2023; Accepted February 7, 2023

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The review describes the syndrome of endogenous intoxication in patients with mental disorders. Oxidative stress, middle-mass endotoxic molecules, impaired functional properties of serum albumin and albumin thiol groups, neurotrophic factors, and enzymes, including monoamine oxidase and semicarbazide-sensitive amine oxidase contribute to the development of endogenous intoxication. Possible pathogenetic mechanisms of the endogenous intoxication development in mental disorders and approaches to its treatment are discussed.

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KEY WORDS: endogenous intoxication, mental disorders, oxidative stress, middle-mass endotoxic molecules, albumin, enzymes, neurotrophic factors

DOI: 10.1134/S0006297923040053

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