REVIEW: Lactobacilli and Klebsiella: Two Opposites in the Fight for Human Health

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Leonid A. Shaposhnikov^1,2, Vladimir I. Tishkov^1,2, and Anastasia A. Pometun^1,2,3,a*

¹Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, 119071 Moscow, Russia

²Faculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia

³Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russia

Received August 9, 2023; Revised September 8, 2023; Accepted September 11, 2023

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The problem of antibiotic resistance is currently very acute. Numerous research and development of new antibacterial drugs are being carried out that could help cope with various infectious agents. One of the promising directions for the search for new antibacterial drugs is the search among the probiotic strains present in the human gastrointestinal tract. This review is devoted to characteristics of one of these probiotic strains that have been studied to date: Limosilactobacillus reuteri. The review discusses its properties, synthesis of various compounds, as well as role of this strain in modulating various systems of the human body. The review also examines key characteristics of one of the most harmful among the currently known pathogenic organisms, Klebsiella, which is significantly resistant to antibiotics existing in medical practice, and also poses a great threat of nosocomial infections. Discussion of characteristics of the two strains, which have opposite effects on human health, may help in creation of new effective antibacterial drugs without significant side effects.

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KEY WORDS: lactobacilli, Limosilactobacillus reuteri, antibiotic resistance, Klebsiella

DOI: 10.1134/S0006297924140050

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