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Biochemistry (Moscow). Papers in Press. Published on March 8, 2021 as Manuscript BM20-312.

Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity

Elizaveta D. Mamontova1,2,3, Svetlana S. Michurina1,2, Iurii S. Stafeev2,a*, Ekaterina L. Sorkina3, Igor A. Sklyanik3, Ekaterina O. Koksharova3, Mikhail Y. Menshikov2, Marina V. Shestakova3, and Yelena V. Parfyonova2,4

1Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia

2Institute of Experimental Cardiology, National Medical Research Centre for Cardiology, 121552 Moscow, Russia

3Diabetes Institute, Endocrinology Research Centre, 117036 Moscow, Russia

4Faculty of Basic Medicine, Lomonosov Moscow State University, 119234 Moscow, Russia

*To whom correspondence should be addressed.

Received November 2, 2020; Revised December 7, 2020; Accepted December 7, 2020
Incretin hormones analogues, including glucagon-like peptide type 1 (GLP-1), exhibit complex glucose-lowering, anorexigenic, and cardioprotective properties. Mechanisms of action of GLP-1 and its analogues are well known for pancreatic β-cells, hepatocytes, and other tissues. Nevertheless, local effects of GLP-1 and its analogues in adipose tissue remain unclear. In the present work effects of the GLP-1 synthetic analogue, liraglutide, on adipogenesis and insulin sensitivity of the 3T3-L1 adipocytes were examined. Enhancement of insulin sensitivity of mature adipocytes by the GLP-1 synthetic analogue liraglutide mediated by adenylate cyclase was demonstrated. The obtained results imply existence of the positive direct insulin-sensitizing effect of liraglutide on mature adipocytes.
KEY WORDS: insulin resistance, adipocyte, GLP-1, incretins

DOI: 10.1134/S000629792103010X