Received March 30, 2000
Flow cytometric studies of rat cerebellum neurons are described under conditions inducing cell death. Using a double labeling technique, discrimination between apoptotic and necrotic cell transformations is demonstrated. Histidine containing neuropeptides were found to regulate cell stability, taking part in selection of the preferable way of neuronal death under oxidative stress.
KEY WORDS: neurons, ischemia, reactive oxygen species, glutamate, apoptosis, necrosis, flow cytometry, histidine containing neuropeptides, carnosine, homocarnosine