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REVIEW: Cancer-Associated Antigens and Antigen Arrays in Serological Diagnostics of Malignant Tumors

P. V. Belousov1*, D. V. Kuprash1, A. Yu. Sazykin2, S. V. Khlgatian2, D. N. Penkov1, Yu. V. Shebzukhov2, and S. A. Nedospasov1,2

1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, 119991 Moscow, Russia; fax: (499) 135-1405; E-mail: belous_p@rambler.ru; kuprash@online.ru

2Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia; fax: (495) 939-4716

* To whom correspondence should be addressed.

Received December 20, 2007; Revision received January 28, 2008
The appearance of antibodies to cancer-associated antigens in biological fluids (particularly, in blood sera) of cancer patients is now a well-established fact, and their detection by immunochemical methods is a promising approach to diagnostics of malignant neoplasms. In this review, we consider some immunobiological aspects of the most extensively studied cancer-associated B-cell antigens, various applications of autoantibodies as cancer biomarkers, and prospects for the use of antigen arrays for improving diagnostic sensitivity.
KEY WORDS: cancer-associated antigens, autoantibodies, serological diagnostics of cancer

DOI: 10.1134/S000629790805009X