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REVIEW: The Role of Motor Proteins in Signal Propagation

F. K. Gyoeva

Institute of Protein Research, Russian Academy of Sciences, ul. Institutskaya 4, 142290 Pushchino, Moscow Region, Russia; fax: +7 (495) 514-0218; E-mail: protres@vega.protres.ru; fgyoeva@gmail.com

Received April 15, 2014; Revision received May 6, 2014
The signaling and transport systems of eucaryotic cells are tightly interconnected: intracellular transport along microtubules and microfilaments is required to position signaling-pathway components, while signaling molecules control activity of motor proteins and their interaction with tracks and cargoes. Recent data, however, give evidence that active transport is engaged in signaling as a means of signal transduction. This review focuses on this specific aspect of the interaction of two systems.
KEY WORDS: kinesin, dynein, myosin, microtubules, microfilaments, signal transduction

DOI: 10.1134/S0006297914090028