REVIEW: Intracellular Mechanisms of Oxygen Sensing

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A. N. Vjotosh^1,2,3,a

¹Sechenov Institute of Evolutionary Physiology and Biochemistry, 194223 St. Petersburg, Russia

²Lesgaft National State University of Physical Education, Sport and Health, 190121 St. Petersburg, Russia

³Mechnikov North-Western State Medical University, 195067 St. Petersburg, Russia

Received May 9, 2019; Revised September 29, 2019; Accepted October 20, 2019

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The review describes molecular mechanisms for sensing oxygen levels in various compartments of animal cell. Several pathways for intracellular oxygen sensing are discussed together with details of functioning of the near-membrane and cytoplasmic pools of molecular components in hypoxic cells. The data on the role of mitochondria in cell sensitivity to a decreased oxygen content are presented. Details of mutual influence of the operational and chronic intracellular mechanisms for detecting the negative gradients of molecular oxygen concentration and their relationship with cell metabolism response to the oxidative stress are discussed.

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KEY WORDS: mitochondria, potassium membrane channels, HIF

DOI: 10.1134/S0006297920010046

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