REVIEW: Competition Involving Biogenic NO

A. A. Nedospasov

Institute of Molecular Genetics, Russian Academy of Sciences, pl. Kurchatova, Moscow, 123182 Russia; fax: (095) 196-0221; E-mail: nedospas@img.ras.ru

Received July 1, 1997

---

This review considers competitive reactions of NO biosynthesis and its interaction with its targets including enzyme competition for arginine, competition between the substrates in the NO-synthase active sites, competitive sources of arginine, multiple states of NO-synthases resulting from competition of reducible cofactors (FAD, FMN, BH₄, heme), competition between aqueous and lipophilic phases for NO resulting in efficient micellar catalysis, and other aspects of competition involving biogenic NO.

---

KEY WORDS: nitric oxide, NO-synthase, competitive substrates, peroxynitrite, S-nitrosothiols, arginine, tetrahydrobiopterin

---