REVIEW: Properties, Functions, and Secretion of Human Myeloperoxidase

J. Arnhold

Institut für Medizinische Physik und Biophysik, Universität Leipzig, Liebigstr. 27, D-04103 Leipzig, Germany; fax: +49-341-9715709; E-mail: arnj@medizin.uni-leipzig.de

Received April 30, 2003

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The heme-containing protein myeloperoxidase is released from stimulated polymorphonuclear leukocytes at sites of inflammation. It is involved in the generation of reactive oxygen and nitrogen species and tissue damage. The general properties and functional aspects of this enzyme are reviewed. Special attention is given to luminescence methods for investigating the release of myeloperoxidase from stimulated cells.

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KEY WORDS: myeloperoxidase, polymorphonuclear leukocytes, reactive oxygen species, hypochlorous acid, luminescence

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