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REVIEW: Antibiotics from Marine Bacteria

V. A. Stonik1,a*, T. N. Makarieva1, and L. K. Shubina1

1Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences (PIBOC), 690022 Vladivostok, Russia

* To whom correspondence should be addressed.

Received July 3, 2020; Revised August 5, 2020; Accepted August 5, 2020
This review discusses main directions and results of the studies on antibiotics produced by bacteria living in the marine environment. In recent years many obligate marine species and strains were studied, diverse metabolites were isolated, and their chemical structures were elucidated. Among them here were natural compounds toxic against tumor cells, pathogenic bacteria, viruses, and malaria plasmodial species; these compounds often had no analogues among the natural products of terrestrial origin. Some isolated compounds form a basis of active ingredients in medicinal preparations used in clinic practice, while others are under different stages of preclinical or clinical studies. Much attention has been paid in recent years to producers of marine-derived antibiotics isolated from the deep-sea habitats, from the surface of marine invertebrates and algae, as well as from symbiotic microorganisms.
KEY WORDS: marine bacteria, antibiotics, cytotoxic effect, antibacterial effect, antifungal effect, antiviral effect, antiparasitic effect

DOI: 10.1134/S0006297920110073